Cellular Dynamics

A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Stem-like CD8+ T cells in dLN maintain stemness and protect antitumor T cells from terminal differentiation in the TME.

KA Connolly, M Kuchroo, A Venkat,…,NS Joshi. Science Immunology 2021.

A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Beta cells are essential drivers of pancreatic ductal adenocarcinoma development

Disentangling the origin of β cells misexpressing pro-tumorigenic hormones in the context of obesity and other stressors.

C Garcia*, A Venkat*, DC McQuaid*,…,S Krishnaswamy, MD Muzumdar. In Revision.

Inferring dynamic regulatory interaction graphs from time series data with perturbations

RiTINI infers time-varying interaction graphs to predict casual behavior of a system. D Bhaskar, S Magruder, E De Brouwer, A Venkat, F Wenkel, G Wolf, S Krishnaswamy. LoG Conference 2023.

Inferring dynamic regulatory interaction graphs from time series data with perturbations

PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens

PD-1 avoids immunopathology by preventing CD8 T cells to attain fully functional state.

M Damo, N Hornick, A Venkat,…,S Krishnaswamy, N Joshi. Nature 2023.

PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens

Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport

TrajectoryNet learns continuous and cell-specific trajectories from longitudinal single-cell data.

A Tong*, M Kuchroo*, S Gupta, A Venkat,…,CL Chaffer, S Krishnaswamy. In Review.

Single-cell analysis reveals transcriptional dynamics in primary parathyroid tissue

The first parathyroid single-cell atlas of primary parathyroid tissue.

A Venkat*, M Carlino*, B Lawton*,…,S Krishnaswamy, D Krause. Genome Research 2024.

Single-cell analysis reveals transcriptional dynamics in primary parathyroid tissue