As the scale and scope of biomedical data exponentially increase, unsupervised machine learning is becoming a crucial step toward scientific discovery. During my Ph.D. at Yale University in the Krishnaswamy Lab, I developed representation learning approaches that learn from geometric structure and reveal patterns that characterize cellular and molecular behavior, especially from single-cell sequencing data. Currently, I am a Postdoctoral Fellow at the Broad Institute to extend these ideas beyond single-cell resolution, bridging knowledge, geometry, and network biology across multiple scales for an integrated, systems-wide approach to discovery and intervention.
My interests are highly interdisciplinary, and I have led collaborations spanning a broad range of research areas, appearing in Nature, Science Immunology, Cell Patterns, Cell Trends in Immunology, and Genome Research. Additionally, my work has been accepted at notable computer science and graph signal procesing conferences, including SampTA, LoG, GSP, and ICASSP.
Stem-like CD8+ T cells in dLN maintain stemness and protect antitumor T cells from terminal differentiation in the TME.
KA Connolly, M Kuchroo, A Venkat,…,NS Joshi. Science Immunology 2021.
GFMMD embeds signals defined on graphs via an optimal witness function.
S Leone, A Tong, G Huguet, A Venkat, G Wolf, S Krishnaswamy. SampTA 2023.
RiTINI infers time-varying interaction graphs to predict casual behavior of a system. D Bhaskar, S Magruder, E De Brouwer, A Venkat, F Wenkel, G Wolf, S Krishnaswamy. LoG Conference 2023.
PD-1 avoids immunopathology by preventing CD8 T cells to attain fully functional state.
M Damo, N Hornick, A Venkat,…,S Krishnaswamy, N Joshi. Nature 2023.
TrajectoryNet learns continuous and cell-specific trajectories from longitudinal single-cell data.
A Tong*, M Kuchroo*, S Gupta, A Venkat,…,CL Chaffer, S Krishnaswamy. Nature In Review.
scMMGAN uses adversarial learning to integrate single-cell and spatial modalities.
M Amodio, SE Youlten, A Venkat,…,CL Chaffer, S Krishnaswamy. Cell Patterns.